Growth hormone is also known as somatotropin. It is a small protein that is made by the pituitary gland and also secreted into the bloodstream. Growth hormone production is controlled by the complex set of hormones produced by the hypothalamus of the brain and in the intestinal tract and pancreas growth hormone also stimulates the production of IGF-1and raises the concentration of glucose and free fatty acids. Growth hormone is 191-amino acid, single chain polypeptide that is somatotropic cells.with in the lateral wing of anterior pituitary gland.
Pituitary glands produce growth hormone in bursts level rise following exercise,trauma, and sleep. Growth hormone is mostly produced at night than day.50% growth hormone secretion occurs during the 3rd and 4th non-rapid eye movement sleep stages. Growth hormone raises during childhood, peaks during puberty and declines from middle age onwards. Growth hormone boosts protein production, promotes the utilization of fat, interferes with the action of insulin and raises blood sugar level.
Structure of Human Growth Hormone:
Human growth hormone is a protein of 191 amino acids and molecular weight of 22,124 daltons.
Regulation of Growth Hormone:
Growth hormone secretion includes:
Clonidine and l-Dopa by stimulating GHRM release
24β2 nicotic against.
Functions of Growth Hormone:
Disorders of Growth Hormone :
Growth Hormone Deficiency
Deficiency of Growth hormone :
- Growth hormone deficiency occurs roughly in 1 in 7,000 births.
- The condition is also a symptom of several genetic diseases, including turners syndrome and proder-Willi syndrome.
- Growth hormone deficiency is treatable in children who have diagnosed early another recovery very well. If it is left untreated the condition can result in shorter than average height and delayed puberty.
- Your body needs growth hormone after puberty also.once you are in the adulthood it maintains your body structure and metabolism.
Causes of growth hormone deficiency :
Ischemic interaction from low blood pressure.
Children with cleft lips and class palates have poorly developed pituitary glands.
Growth hormone deficiency is not present at birth may be caused by the tumor in the brain.
Chronic renal insufficiency.
Symptoms of growth hormone deficiency :
Children with growth hormone deficiency are shorter than peers and have younger, rounded faces.
Children with growth hormone deficiency may also be chubby or fat around the abdomen.
The main symptom is delayed puberty and in some instances, sexual development is halted.
Reduced sex hormone binding globalism.
Reduced muscle mass and strength.
Baldness in men.
Reduced bone mass and osteoporosis.
Psychological symptoms of Growth Hormone Deficiency
Psychological symptoms may also occur
Lack of concentration.
It is a condition in which the pituitary gland secretes growth hormone on after normal growth of selection and other organs incomplete.It causes a benign tumor of the pituitary gland.
Acromegaly means enlarged extremities
Type 2 diabetes
It is a rare condition that causes abnormal growth is children change is most noticeable in terms of height but girth is affected as well. It occurs when your child’s pituitary gland makes too much of growth hormone.
Irregular menstrual periods
It is a condition of short stature it is a rare disease that results from low production of hormones in the pituitary gland.
It is of two types :
We head, truck and limbs are proportionate to catch other but much smaller than overage sized persons.
It is most common body parts are disproportionate.
Ex: Arms and legs are shorter than the trunk.
Diagnosis of Growth Hormone :
The child does not meet their height and weight milestones.
Blood test: Can measure Growth hormone in the body.
X-Ray: Level of bone growth
Indirectly hormonal criteria
Kidney and thyroid function test: Can determine how the body is producing and using the hormone.
MRI Scan: For any tumor or damage to the pituitary gland or brain injury.
Severe growth hormone deficiency in childhood :
Delayed physical maturation
Delayed Bone age
Low levels of IGF-1,IGF-2.
Homeopathy Treatment of Growth Hormone Deficiency:
Growth hormone deficiency can be treated by homeopathic medication under the age of 18 years for girls and 21 years for boys. Some homeopathic medicines are
– Baryta Carb
Dr Ankiredy’s Homeopathy is the best homeopathy clinic in Hyderabad with 25 years of experience and treated more than 95000 patients. They provide best homeopathic medication to treat Growth hormone deficiency.